Skincare Routine While on Isotretinoin: Dermatologist Tips
Gentle Cleansing: Choose Rinses for Delicate, Dry Skin
I learned to cherish soft rituals when my skin became fragile on isotretinoin; a gentle, fragrance-free rinse feels comforting and removes impurities without overdrying.
Choose creamy, soap-free cleansers that preserve natural oils, rinse with lukewarm water, and avoid vigorous scrubbing or abrasive cloths that aggravate flakes. Patch-test a new product on your jawline and wait 48 hours.
Apply moisturizer to damp skin to seal hydration, use occlusives at night, and call your dermatologist if redness persists; Teh small swaps keep you comfortable and healing steadily. Bring gentle cleansers when traveling.
Hydration Hierarchy: Moisturizers, Serums, and Occlusives Explained

Start with a simple moisturizer that rebuilds teh skin’s barrier; during isotretinoin therapy, cream or lotion formulas with ceramides, glycerin and hyaluronic acid are lifesavers. Think of moisturizers as the foundation — lightweight ones for daytime, richer creams at night to restore lost lipids and comfort.
Serums deliver targeted support: humectant-rich serums (hyaluronic acid, panthenol) draw in moisture, while peptide or niacinamide serums address sensitivity and redness. Apply serums onto slightly damp skin before your moisturizer so active ingredients penetrate without stripping the fragile barrier that isotretinoin makes more vulnerable.
Occlusives seal everything in. Use petrolatum or plant butters sparingly on very dry patches, lips and around the nostrils to prevent transepidermal water loss. Layering in the right order — damp skin, serum, moisturizer then occlusive when neccessary — optimizes hydration and comfort. Reapply sparingly at night for lasting relief and comfort.
Sun Protection Daily: Broad Spectrum Spf and Habits
The morning sun looks innocent, but for anyone on isotretinoin it’s risky. Use a broad-spectrum SPF 30+ every morning, apply a generous dose to face and neck, and wait a couple minutes for absorption. Seperate face and body protocols help coverage.
Reapply every two hours when outdoors and after swimming or heavy sweating. Pair sunscreen with physical barriers: UPF clothing, hats, and sunglasses. Time outdoor plans for early morning or late afternoon to reduce UV exposure.
Keep a small sunscreen in your bag and set phone reminders to reapply; dry, peeling skin from therapy makes burns more likely. These daily habits lower photosensitivity, protect against long-term damage, and make the treatment experience much more comfortable.
Avoid Irritants: No Retinoids, Acids, or Harsh Exfoliants

As a dermatologist I tell patients starting isotretinoin that their skin will feel fragile and tight; it's an exciting but delicate time. Daily routines should favor soothing, low-activity products — skip abrasive scrubs, strong chemical peels, and layered active treatments. Overstripping the barrier leads to redness, painful fissures, and delayed healing, making recovery longer.
Practical steps help: read ingredient labels, choose fragrance-free formulas with ceramides, hyaluronic acid, and gentle emollients, and perform small patch tests before new items. Gentle antioxidants like vitamin E or niacinamide can calm irritation, improve barrier function. Definately wait until your follow-up visit before reintroducing potent agents or scheduling in-office procedures, and always coordinate changes with your dermatologist to avoid set-backs.
Lip and Nose Care: Targeted Healing and Protection
Lips often bear the first, most visible signs of dryness on isotretinoin; mornings can feel tight and flakey, so start simple. Apply a thick, fragrance‑free balm after cleansing and before bed to seal moisture. Keep a tube handy during the day and reapply after eating or drinking.
Nasal passages can crust and bleed—use a saline spray to gently hydrate and a thin layer of petroleum or medical‑grade ointment inside the nostrils to protect fragile skin. Avoid picking crusts; softening then trimming with clean tools reduces infection risk. If frequent nosebleeds occur, tell your dermatologist.
Small rituals help: sip water, humidify your bedroom, and choose nonirritating toothpaste and lip products. Anticipate change and be patient; most issues improve after dose adjustments or treatment end. For persistent problems, a clinic visit will Acommodate targeted care and provide prescription options, follow-up, and reassurance.
Makeup, Hair Removal, Procedures: Safety While on Therapy
I learned to simplify makeup on isotretinoin: lighter, noncomedogenic products, mineral powders and fragrance-free tints keep cover-up minimal and skin breathing. Remove thoroughly with gentle cleanser at night to avoid buildup and extra irritation for sensitive, dry skin.
Shaving and waxing need thought: electric shavers or hair clippers usually cause less trauma than blades; wait several months after starting treatment before consenting to aggressive procedures. Communicate medication dates with your technician and sunscreen.
Injectables, lasers and deep peels can provoke delayed healing; dermatologists often advise postponing invasive cosmetic work to reduce scarring risk. Always get explicit medical clearance and favour conservative, single-session approaches if needed and limit exposure.
Keep emergency contact with your prescriber and report severe redness, bleeding or infections promptly. Occassionally reactions occur — document dates and products used, and stop suspect items untill reviewed to protect progress.
https://www.nhs.uk/conditions/isotretinoin/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513411/